Impact

The Molecular Therapeutics Initiative launches from UC Berkeley to catalyze the development of new disease therapies and to train the next-generation of drug discoverers

MTI member Markita Landry wins the Blavatnik Prize

Julia Schaletzky named as Executive Director of the Molecular Therapeutics Initiative

Ziyang Zhang awarded the NIH Director's New Innovator Award

Jennifer Doudna featured in Fast Company Cover article as one of the 10 most innovative people of the last 10 years

Helen Bateup part of research team awarded $12 MM grant from CIRM

Small molecule modulation of protein corona for deep plasma proteome profiling

Stress response silencing by an E3 ligase mutated in neurodegeneration

Lung and liver editing by lipid nanoparticle delivery of a stable CRISPR-Cas9 ribonucleoprotein

SARS-CoV-2 Nsp1 traps RNA in the nucleus to escape immune detection

TFEB controls expression of human syncytins during cell-cell fusion

Covalent degrader of the oncogenic transcription factor beta-catenin

Targeted Protein Localization by Covalent 14−3−3 Recruitment

Genome integrity sensing by the broad-spectrum Hachiman antiphage defense complex

Incorporation of Multiple β2-Hydroxy Acids into a Protein In Vivo Using an Orthogonal Aminoacyl-tRNA Synthetase

Spectrin mediates 3D-specific matrix stress-relaxation response in neural stem cell lineage commitment

Birth of protein folds and functions in the virome

DCAF16-Based Covalent Handle for the Rational Design of Monovalent Degraders

Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

Near-infrared nanosensors enable optical imaging of oxytocin with selectivity over vasopressin in acute mouse brain slices

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes

Long-term super-resolution inner mitochondrial membrane imaging with a lipid probe

Mechanism and cellular function of direct membrane binding by the ESCRT and ERES-associated Ca2+-sensor ALG-2

Rational Chemical Design of Molecular Glue Degraders

Engineered Glucose Oxidase-Carbon Nanotube Conjugates for Tissue-Translatable Glucose Nanosensors

Mechanosensitive stem cell fate choice is instructed by dynamic fluctuations in activation of Rho GTPases

p300 is an obligate integrator of combinatorial transcription factor inputs

Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1

The viral packaging motor potentiates Kaposi's sarcoma-associated herpesvirus gene expression late in infection

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis

Orphan quality control shapes network dynamics and gene expression

Expanding the substrate scope of PylRS enzymes to include non-⍺-amino acids in vitro and in vivo

Genome expansion by a CRISPR trimmer-integrase

Peptide-mediated delivery of CRISPR enzymes for the efficient editing of primary human lymphocytes

Deubiquitinase-targeting chimeras for targeted protein stabilization

Identification of structurally diverse small molecule inhibitors of FSP1

Vaccinia virus D10 has broad decapping activity that is regulated by mRNA splicing

Tuning levels of low-complexity domain interactions to modulate endogenous oncogenic transcription

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells

Raptor downregulation rescues neuronal phenotypes in mouse models of Tuberous Sclerosis Complex

Supervised learning model predicts protein adsorption to carbon nanotubes

Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

Structural basis and regulation of the reductive stress response

Mechanistic basis for ubiquitin modulation of a protein energy landscape

NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C

In vivo-directed evolution of adeno-associated virus in the primate retina

Gene expression and cell identity controlled by anaphase-promoting complex

Dimerization quality control ensures neuronal development and survival

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

Eikon Therapeutics

Intellia Therapeutics

Nurix

Frontier Medicines

Lyterian Therapeutics

Vicinitas Therapeutics

Caribou Biosciences

Scribe Therapeutics

Mammoth Biosciences

4D Molecular Therapeutics